Non-Asbestos Cause of Malignant Mesothelioma

A cluster of malignant mesothelioma case in Biancavilla, has been reported. In the areas located near the city, a fibrous amphibole, which was fluoro-edenite, was identified and was claimed to be the cause of malignant mesothelioma. The mineral is very similar in composition and morphology to the actinolitetremolite groups of minerals. A study of samples of sputum from subjects that live in the area revealed fluoro-edenite fiber in fifty percent of the subjects; the length of these fibers ranged from twenty to forty millimeters.

Fluoro-edenite fibers were found also in the autopsy samples of a women that died of mesothelioma and in lung and lymph node tissues of goats that live in the local areas. The exposure to organic fiber has been suspected to be the cause of malignant mesothelioma in sugarcane workers that were potentially exposed to the fibers of crystalline silica of plant origin. But, there have been no convulsive studies published, and a case control study of workers in the Hawaii sugarcane industry found no convincing evidence of significant excess of malignant mesothelioma in workers of sugarcane.

Carbon Nanotubes

To date no case of mesothelioma have been associated with the exposure to man-made mineral fiber. But, recently the concern has been raised about the risk of developing the malignant cancer form the exposure to carbon nanotubes (CNTs) and other ratio of high-aspect nanoparticles which are made from other materials such as silver, silica, and nickel. Carbon nanotubes are indeed essential products of nanotechnology, which are commonly used in a wide range of applications which includes medicine and electronics. Comparisons can be made now between the data obtained on the pulmonary and the cellular impacts of CNTs as well as asbestos, and in particular, the asbestos fiber features which relate to toxicity. Carbon nanotubes can possibly occur as the compact tangles of nanotubes or as straighter, longer, fibers; it is with the latter that toxiologic is concerned with.

A number of experimental studies of implantation of CNTs into the peritoneal cavity of mice have showed that the long fibers of CNTs generated a similar or perhaps even greater degree of inflammation and fibrosis than that which is produced by long amosite asbestos. Neither short, tangled CNTs nor short asbestos fibers produced any serious inflammation.

The main key for pathogenicity occurred between 15 and 20 mm. A similar study carried out in the pleural cavity indicated similar findings. A couple of recent studies have shown the occurrence of malignant mesothelioma in genetically modified malignant cancer-sensitized mice 38 and in the more conventional rats that are exposed to intraperitoneal or even intrascrotal administration. As a result, CNTs can evince similar shape, which is elongated fiber-like compounds, similar diameter, and even similar cytotoxicity as the common asbestos. In addition they can generate DNA damage and have more or less the same impact in peritoneal cavity in animals. But to date there is no clear and conclusive information with regard to human exposures.

Reminiscence of the aforementioned findings, it has been rather more urgent to find out how we can protect ourselves from various causes of malignant mesothelioma.

You May Also Like

About the Author: Dr Strange

Leave a Reply

Your email address will not be published. Required fields are marked *